The microcell is optimized for an ambient temperature of 10 to 30 °C. It is possible to run the cell within 0 °C and 60 °C without damaging it. However please note that operation at higher temperature decreases the ozone production and its solubility in water. Furthermore the ozone loss through decomposition reactions is increased.

The electrolytic ozone generation is independent of pressure to a large extent. Microcells are designed to be operated in pressurized lines. The operation under pressure has the advantage of higher solubility and the dispersal of ozone is increased. The solubility of ozone is proportional to the system pressure.